Synovex Plus: Product Information

SYNOVEX PLUS- trenbolone acetate and estradiol benzoate implant
Zoetis Inc.

Synovex Plus® (trenbolone acetate and estradiol benzoate)

IMPLANTS FOR STEERS AND HEIFERS FED IN CONFINEMENT FOR SLAUGHTER

200 mg trenbolone acetate and 28 mg estradiol benzoate

Synovex Plus (trenbolone acetate and estradiol benzoate) is a growth promoting implant containing 200 mg of trenbolone acetate and 28 mg of estradiol benzoate. Each implant consists of 8 pellets. Ten implants are provided in each cartridge.

NOTE

Synovex Plus is not better for increased average daily gain than Synovex Choice (100 mg trenbolone acetate/14 mg estradiol benzoate) in steers fed in confinement for slaughter. Studies have demonstrated that the administration of Synovex Plus can result in decreased marbling scores when compared to non-implanted steers and heifers.

DOSAGE

One implant (eight pellets), containing 200 mg of trenbolone acetate and 28 mg of estradiol benzoate, is administered to each steer or heifer by subcutaneous implantation in the middle one‑third of the ear.

The ten-dose cartridge of Synovex Plus is designed to be used exclusively with a Synovex implanting device.

WARNING

Not for use in humans. For animal use only. Not for dairy or beef replacement heifers. Implant pellets in ear only. Any other location is a violation of Federal law. Do not attempt salvage of implanted site for human or animal food.

A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.

DO NOT USE IN VEAL CALVES.
NOT FOR USE IN HUMANS.
FOR ANIMAL USE ONLY.

CAUTION

Bulling, vaginal and rectal prolapse, udder development, ventral edema and elevated tailheads have occasionally been reported in heifers administered Synovex Plus implants.

DIRECTIONS

Implant complete contents of one cartridge cell per steer or heifer. Approved implantation technique is fully described in the fold-out carton section.
NOTE: Never sacrifice careful, clean technique for speed of implantation.

STORAGE

Store unopened product at controlled room temperature 20°-25°C (68°-77°F) with excursions between 15°-30°C (59°-86°F). Avoid excessive heat and humidity. Use product before the expiration date on the label.

Once the pouch is opened, unused product may be stored in the end-folded pouch (away from light) for up to six months under refrigerated conditions 2°-8°C (36°-47°F) or at room temperature 20°-25°C (68°-77°F) with excursions between 15°-30°C (59°-86°F) for up to one month.

INDICATIONS FOR USE

Synovex Plus is recommended for increased rate of weight gain and improved feed efficiency in steers and for increased rate of weight gain in heifers fed in confinement for slaughter. Do not use in veal calves. Effectiveness and animal safety in veal calves have not been established.

NET CONTENTS

One pouch contains ten 10-dose cartridges (100 implants).

Manufactured By A Non-Sterilizing Process
Keep this and all drugs out of the reach of children.
Restricted Drug (California)—Use Only As Directed.
IMPORTANT: Read ALL sides of carton
NADA 141-043, Approved by FDA
zoetis
Distributed by:
Zoetis Inc.
Kalamazoo, MI 49007
6053J
11888301

PRINCIPAL DISPLAY PANEL — 10 Cartridge Implant Carton

10 Cartridge Implant Carton
(click image for full-size original)

Ear diagram instructions
(click image for full-size original)
Synovex SX10 Gun
(click image for full-size original)

SYNOVEX PLUS
trenbolone acetate and estradiol benzoate implant
Product Information
Product Type OTC ANIMAL DRUG Item Code (Source) NDC:54771-3904
Route of Administration SUBCUTANEOUS DEA Schedule
Active Ingredient/Active Moiety
Ingredient Name Basis of Strength Strength
TRENBOLONE ACETATE (TRENBOLONE) TRENBOLONE ACETATE 200 mg
ESTRADIOL BENZOATE (ESTRADIOL) ESTRADIOL BENZOATE 28 mg
Packaging
# Item Code Package Description Multilevel Packaging
1 NDC:54771-3904-1 1 POUCH in 1 BOX contains a POUCH
1 10 CARTRIDGE in 1 POUCH This package is contained within the BOX (54771-3904-1) and contains a CARTRIDGE
1 10 IMPLANT in 1 CARTRIDGE This package is contained within a POUCH and a BOX (54771-3904-1)
Marketing Information
Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
NADA NADA141043 11/07/2014
Labeler — Zoetis Inc. (828851555)

Revised: 05/2020 Zoetis Inc.

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