Sodium Bicarbonate: Product Information

SODIUM BICARBONATE- sodium bicarbonate injection
MWI (VetOne)

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

INDICATIONS:

For treatment of metabolic acidosis. See package insert for specific indications.

Active Ingredient: Each mL contains:

Sodium Bicarbonate……………………..84 mg

(equal to 1 mEq/mL)

Inactive Ingredient:

Water for Injection………………………q.s.

Dosage and Administration:

Administer intravenously. See package insert for complete directions for use and dosage information.

Take Time Observe Label Directions

NDC 13985-567-01

100 mL

VetOne®

Sodium Bicarbonate 8.4%

Injection

Sterile Solution

Single Dose Vial

V1 510186

Net Contents: 100 mL

Made In USA

Manufactured by:

Nova-Tech

Grand Island, NE 68801

for Neogen Corporation

RMS# 92-1080

NTI# 18-9078

Distributed by: MWI

Boise, ID 83705

www.VetOne.net

Rev. 10/19

Lot No.:

Exp. Date

Storage:

Store at a temperature between 15°-30°C (59°-86°F). Avoid freezing.

Keep out of reach of children.

For veterinary use only.

Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Warning:

This is a sterile single dose vial. No preservatives have been added. Discard unused portion after use. Do not use if solution is hazy, cloudy, or contains a precipitate. The total osmolar concentration of this product is approximately 2000 mOsm/L.

Read entire package insert before use.

Package Insert

VetOne®

SODIUM BICARBONATE 8.4%

Injection

STERILE NONPYROGENIC SOLUTION

FOR VETERINARY USE ONLY

DESCRIPTION: Sodium Bicarbonate 8.4% is a sterile
nonpyrogenic preparation of sodium bicarbonate
(NaHCO3) in Water for Injection. Each 100 mL contains
8.4 grams of sodium bicarbonate (100 mEq/100 mL
each of sodium and bicarbonate). This concentrated
solution has an approximate pH of 7.8.

ACTIONS: Sodium Bicarbonate is useful in the
treatment of metabolic acidosis due to a wide variety of
causes. Sodium Bicarbonate therapy increases plasma
bicarbonate, buffers excess hydrogen ion concentration,
raises blood pH and reverses the clinical manifestations
of acidosis. Sodium Bicarbonate also alkalinizes the
urine.

INDICATIONS: Sodium Bicarbonate is indicated in the
treatment of metabolic acidosis which may be due to
severe renal disease, uncontrolled diabetes, circulatory
insufficiency due to shock or severe dehydration,
cardiac arrest and severe primary lactic acidosis.
Sodium Bicarbonate is also indicated in severe diarrhea
which is often accompanied by a significant loss of
bicarbonate. Sodium Bicarbonate 8.4% is indicated in
the treatment of metabolic acidosis in cattle, horses,
sheep, swine and dogs depending upon causative
factor.

CONTRAINDICATIONS: Sodium Bicarbonate is contraindicated
in animals losing chloride by vomiting and in
animals receiving diuretics known to produce a
hypochloremic alkalosis.

PRECAUTIONS: Bicarbonate therapy is directed at
producing a substantial correction of low total CO2
content and blood pH, but risks of overdosage and
alkalosis should be avoided. Repeated fractional doses
and periodic monitoring by appropriate laboratory tests
are therefore recommended to minimize the possibility
of overdosage. Sodium Bicarbonate addition to
parenteral solutions containing calcium should be
avoided except where compatibility has been previously
established. Precipitation or haze may result from
sodium bicarbonate-calcium admixtures, and the
resulting solution should not be administered.

DOSAGE AND ADMINISTRATION: Sodium Bicarbonate
8.4% is injected intravenously. Caution should be taken
in emergencies where very rapid infusion of large
quantities of bicarbonate is indicated, such as cardiac
arrest. Sodium Bicarbonate solutions are hypertonic
and may produce an undesirable rise in plasma sodium
concentration during the process of correction of
metabolic acidosis. During cardiac arrest, however, the
risks from acidosis exceed those of hypernatremia. In
cattle and horses, 200 to 300 mL of 8.4% solution may
be given undiluted by rapid infusion using a needle and
syringe.

Sodium Bicarbonate 8.4% solution is often added to other
intravenous fluids for the less urgent forms of metabolic
acidosis. The amount of bicarbonate to be given over a
4 to 8 hour period is approximately 2 to 5 mEq per kg of
body weight (1-2.5 mL/lb body weight) depending upon
the severity of the acidosis as judged by the lowering of
total CO2 content, blood pH and clinical condition of the
animal.

Bicarbonate therapy should always be planned in
stepwise fashion since the degree of response from a
given dose is not precisely predictable. Initially, an
infusion of 2 to 5 mEq per kg of body weight over a
period of 4 to 8 hours will produce a measurable
improvement in the abnormal acid-base status of the
blood. Completion of therapy is dependent upon the
clinical response of the animal. If severe symptoms
have abated, then frequency of administration and size
of the dose should be reduced.

OVERDOSAGES: In case alkalosis occurs, the
bicarbonate should be stopped and the animal
managed according to the degree of alkalosis present.
Sodium chloride injection (0.9%) may be given intravenously;
potassium chloride also may be indicated if
there is hypokalemia. Severe alkalosis may be accompanied
by hyperirritability or tetany, and these
symptoms may be controlled by calcium gluconate. An
acidifying agent such as ammonium chloride may also
be indicated in severe alkalosis.

HOW SUPPLIED: Sodium Bicarbonate 8.4% is
supplied in a 100 mL single dose vial.

WARNING: This is a sterile single dose vial. No preservatives
have been added. Discard unused portion after
use. Do not use if solution is hazy, cloudy or contains a
precipitate.

Store at a temperature between 15°-30° C (59°-86° F).

CAUTION: Federal law (U.S.A.) restricts this drug touse by or on the order of a licensed veterinarian.

Distributed by: MWI

Boise, ID 83705

(888) 694-8381

www.VetOne.net

RMS# 92-1079

NTI# 18-9078

Rev. 06/14

VetOne®

Sodium Bicarbonate

Sodium Bicarbonate
(click image for full-size original)

SODIUM BICARBONATE sodium bicarbonate injection
Product Information
Product Type PRESCRIPTION ANIMAL DRUG Item Code (Source) NDC:13985-567
Route of Administration INTRAVENOUS DEA Schedule
Active Ingredient/Active Moiety
Ingredient Name Basis of Strength Strength
SODIUM BICARBONATE (BICARBONATE ION) SODIUM BICARBONATE 84 mg in 1 mL
Inactive Ingredients
Ingredient Name Strength
WATER
Packaging
# Item Code Package Description Multilevel Packaging
1 NDC:13985-567-01 100 mL in 1 VIAL, SINGLE-USE None
Marketing Information
Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
unapproved drug other 11/01/2014
Labeler — MWI (VetOne) (019926120)
Registrant — Nova-Tech, Inc (196078976)
Establishment
Name Address ID/FEI Operations
Nova-Tech, Inc 196078976 manufacture

Revised: 11/2019 MWI (VetOne)

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