Safe-guard: Product Information

SAFE-GUARD- fenbendazole granule
Merck Sharp & Dohme Corp.

Directions: The daily dose for Safe-Guard® Canine is 50 mg/kg (22.7 mg/lb) of body weight. You should weigh your dog to make sure you are using the right dose; i.e. correct gram amount and appropriate number of pouches.

Your dog must be treated with the following dose for 3 days in a row.

Dog Weight
Pouch Size
(Daily Dose)
Combine pouches to obtain recommended daily dosage.
101 gram
11 to 20 2 gram
21 to 30*1 gram + 2 gram
31 to 40 4 gram
41 to 50*1 gram + 4 gram
51 to 60*2 gram + 4 gram
61 to 80*Two 4 gram
Over 80*
Mix daily dose with a small amount of the usual food. Make sure your dog eats all the medicated food. You may need to moisten dry dog food to aid mixing.
Repeat the dose for 3 days in a row.


Recommended Deworming Schedule:

Schedule may vary depending on the climate where you live and the activity of your dog. The following schedule should be used as a general guideline.

  • Weaned pups (6-8 weeks of age) should be dewormed at 6, 8, 10 and 12 weeks of age.
  • Treat the dam at the same time as the puppies.
  • Dogs over 6 months of age should be dewormed at least twice each year.

Diagnosis of Parasites: Consult your veterinarian for help in the diagnosis, treatment and control of parasitism. Specific diagnoses require laboratory testing. Dogs can become infected with several different kinds of tapeworms. Safe-Guard® Canine only kills Taenia species of tapeworms. If you continue to see tapeworm segments in your dog’s stool after treatment with Safe-Guard® Canine, consult your veterinarian.

Roundworms and hookworms may pose serious human health risks; regular deworming may help reduce those risks.

Product Use: Safe-Guard® Canine is safe for use in puppies 6 weeks or older and adult dogs, including pregnant bitches. Do not deworm a dog or puppy that is sick. Consult your veterinarian for diagnosis of the illness.

Adverse Reactions: In U.S. clinical studies 3 of 240 dogs (about 1% of the treated dogs) had vomiting associated with the use of the product.

Storage: Store at controlled room temperature 68-77°F (20-25°C).

Questions? Comments?

To obtain product information including material safety data sheets (MSDS) or to report a suspected adverse reaction, call 1-800-441-8272.

Distributed by:
Intervet Inc (d/b/a Merck Animal Health)
Madison, NJ 07940

NADA #121-473, Approved by FDA

Made in Austria


Animal Health



For dogs only, 6 weeks and older.

Drug Facts:
Active ingredients (in each dosage unit): Fenbendazole Granules 22.2% (222 mg/g)

Uses: For the treatment and control of:

  • Tapeworms
    (Taenia pisiformis)
  • Roundworms
    (Toxocara canis, Toxascaris leonina)
  • Hookworms
    (Ancylostoma caninum, Uncinaria stenocephala)
  • Whipworms
    (Trichuris vulpis)

Consult your veterinarian for assistance in the
diagnosis, treatment and control of parasitism.


(click image for full-size original)
fenbendazole granule
Product Information
Product Type OTC ANIMAL DRUG Item Code (Source) NDC:57926-483
Route of Administration ORAL DEA Schedule
Active Ingredient/Active Moiety
Ingredient Name Basis of Strength Strength
# Item Code Package Description Multilevel Packaging
1 NDC:57926-483-01 3 POUCH in 1 CARTON contains a POUCH
1 1 g in 1 POUCH This package is contained within the CARTON (57926-483-01)
2 NDC:57926-483-02 3 POUCH in 1 CARTON contains a POUCH
2 2 g in 1 POUCH This package is contained within the CARTON (57926-483-02)
3 NDC:57926-483-04 3 POUCH in 1 CARTON contains a POUCH
3 4 g in 1 POUCH This package is contained within the CARTON (57926-483-04)
Marketing Information
Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
NADA NADA121473 01/05/1979
Labeler — Merck Sharp & Dohme Corp. (001317601)
Name Address ID/FEI Operations
Zhejiang Apeloa Kangyu Pharmaceutical Co., Ltd. 420823163 API MANUFACTURE

Revised: 01/2022 Merck Sharp & Dohme Corp. provides trustworthy package insert and label information about marketed drugs as submitted by manufacturers to the U.S. Food and Drug Administration. Package information is not reviewed or updated separately by Every individual animal healthcare product label entry contains a unique identifier which can be used to secure further details directly from the U.S. National Institutes of Health and/or the FDA.

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