LongRange: Product Information

LONGRANGE- eprinomectin injection, solution
Merial, Inc.

Extended-Release Injectable Parasiticide
5% Sterile Solution

For the Treatment and Control of Internal and External Parasites of Cattle on Pasture with Persistent Effectiveness

Not for use in female dairy cattle 20 months of age or older, including dry dairy cows. Not for use in calves to be processed for veal.

Not for use in breeding bulls, or in calves less than 3 months of age.

Not for use in cattle managed in feedlots or under intensive rotational grazing.

CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

DESCRIPTION

LONGRANGE® (eprinomectin) is a ready-to-use, sterile injectable preparation containing eprinomectin, a member of the macrocyclic lactone class of antiparasitics. Each mL of LONGRANGE contains 50 mg of eprinomectin in a co-solvent system of N-methyl-2-pyrrolidone (30% v/v) and triacetin (qs), along with 50 mg of poly-lactide-co-glycolic-acid 75:25 (PLGA), a polymer that allows a slow release of eprinomectin from the formulation, thereby maintaining a prolonged duration of product effectiveness. Butylated hydroxytoluene (0.2 mg/mL) acts as an antioxidant in the formulation.

The chemical name of eprinomectin is 4″-deoxy-4″-epiacetylamino-avermectin B1 . It is a semi-synthetic member of the avermectin family of compounds consisting of a mixture of two homologous components, B1a and B1b , which differ by a single methylene group at C26 .

Chemical Structure
(click image for full-size original)

INDICATIONS FOR USE

LONGRANGE, when administered at the recommended dose volume of 1 mL per 110 lb (50 kg) body weight, is effective in the treatment and control of the following internal and external parasites of cattle:

Gastrointestinal Roundworms Lungworms
Bunostomum phlebotomum – Adults and L4 Dictyocaulus viviparus – Adults
Cooperia oncophora – Adults and L4
Cooperia punctata – Adults and L4
Cooperia surnabada – Adults and L4 Grubs
Haemonchus placei – Adults Hypoderma bovis
Oesophagostomum radiatum – Adults
Ostertagia lyrata – Adults Mites
Ostertagia ostertagi – Adults, L4 , and inhibited L4 Sarcoptes scabiei var. bovis
Trichostrongylus axei – Adults and L4
Trichostrongylus colubriformis – Adults

Persistent Activity

LONGRANGE has been proven to effectively protect cattle from reinfection with the following parasites for the indicated amounts of time following treatment:

Parasites Durations of Persistent Effectiveness
Gastrointestinal Roundworms
Bunostomum phlebotomum 150 days
Cooperia oncophora 100 days
Cooperia punctata 100 days
Haemonchus placei 120 days
Oesophagostomum radiatum 120 days
Ostertagia lyrata 120 days
Ostertagia ostertagi 120 days
Trichostrongylus axei 100 days
Lungworms
Dictyocaulus viviparus 150 days

DOSAGE AND ADMINISTRATION

LONGRANGE® (eprinomectin) should be given only by subcutaneous injection in front of the shoulder at the recommended dosage level of 1 mg eprinomectin per kg body weight (1 mL per 110 lb body weight).

Each mL of LONGRANGE contains 50 mg of eprinomectin, sufficient to treat 110 lb (50 kg) body weight. Divide doses greater than 10 mL between two injection sites to reduce occasional discomfort or site reaction.

Body Weight (lb)Dose Volume (mL)
1101
2202
3303
4404
5505
6606
7707
8808
9909
110010

LONGRANGE is to be given subcutaneously only. Animals should be appropriately restrained to achieve the proper route of administration. Inject under the loose skin in front of the shoulder (see illustration) using a 16 or 18 gauge, ½ to ¾ inch needle.

Sanitize the injection site by applying a suitable disinfectant. Clean, properly disinfected needles should be used to reduce the potential for injection site infections.

Figure
(click image for full-size original)

100 mL bottle size: Use only polypropylene syringes. Not for use with polycarbonate syringe material. If syringe material is not known, contact the syringe manufacturer prior to use for identification. Alternatively, a 50-mL polypropylene repeater syringe compatible with LONGRANGE may be used. To obtain a list of compatible equipment, contact Merial at 1-888-637-4251. Do not use beyond 3 months after stopper has been punctured. Discard bottle after 15 stopper punctures. LONGRANGE should not be stored in the repeater syringe.

250 mL and 500 mL bottle sizes: Use only automatic syringe equipment provided by Merial. To obtain compatible equipment, contact Merial at 1-888-637-4251 or your veterinarian. LONGRANGE should not be stored in automatic syringe equipment. Automatic syringe equipment should be thoroughly cleaned after each use. Discard bottle after one stopper puncture with draw-off spike.

Alternatively, a 50-mL polypropylene repeater syringe compatible with LONGRANGE may be used. To obtain a list of compatible equipment, contact Merial at 1-888-637-4251. When using a repeater syringe, do not use beyond 3 months after stopper has been punctured. Discard bottle after 15 punctures. LONGRANGE should not be stored in the repeater syringe.

No special handling or protective clothing is necessary.

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