EPRINEX Pour-On For Beef and Dairy Cattle: Product Information

EPRINEX POUR-ON FOR BEEF AND DAIRY CATTLE- eprinomectin solution
Boehringer Ingelheim Animal Health USA Inc.

Approved by FDA under NADA # 141-079

Parasiticide

Contains 5 mg eprinomectin/mL

Not for use in calves to be processed for veal.

INTRODUCTION

EPRINEX Pour-On delivers effective internal and external parasite control in one application. Discovered and developed by scientists from Merck Research Laboratories, EPRINEX Pour-On contains eprinomectin, a unique avermectin. Its broad-spectrum efficacy in a weatherproof formulation, margin of safety, zero slaughter withdrawal and zero milk discard, make it a convenient product for parasite control in beef and dairy cattle, including lactating dairy cattle.

MODE OF ACTION

Eprinomectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells.

This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).

The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.

INDICATIONS

EPRINEX (eprinomectin) Pour-On is indicated for the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle.

Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight, EPRINEX Pour-On is indicated for the effective treatment and control of the following parasites.

Gastrointestinal Roundworms

Haemonchus placei

(adults and L4)

Ostertagia ostertagi (including inhibited L4)

(adults and L4)

Trichostrongylus axei

(adults and L4)

Trichostrongylus colubriformis

(adults and L4)

Trichostrongylus longispicularis

(adults only)

Cooperia oncophora

(adults and L4)

Cooperia punctata

(adults and L4)

Cooperia surnabada

(adults and L4)

Nematodirus helvetianus

(adults and L4)

Oesophagostomum radiatum

(adults and L4)

Bunostomum phlebotomum

(adults and L4)

Strongyloides papillosus

(adults only)

Trichuris spp.

(adults only)

Lungworms

Dictyocaulus viviparus

(adults and L4)

Cattle Grubs (all parasitic stages)

Hypoderma lineatum, Hypoderma bovis

Lice

Damalinia bovis, Linognathus vituli, Haematopinus

eurysternus, Solenopotes capillatus

Mange Mites

Chorioptes bovis, Sarcoptes scabiei

Horn Flies

Haematobia irritans

Persistent Activity

EPRINEX (eprinomectin) Pour-On for Beef and Dairy Cattle has been proved to effectively control infections and to protect cattle from re-infection with Dictyocaulus viviparus for 21 days after treatment and Haematobia irritans for 7 days after treatment.

Use Conditions

Varying weather conditions, including rainfall, do not affect the efficacy of EPRINEX Pour-On.

Management Considerations for Treatment of External Parasites

For best results EPRINEX Pour-On should be applied to all cattle in the herd. Cattle introduced to the herd later should be treated prior to introduction. Consult your veterinarian or an entomologist for the most effective timing of applications for the control of external parasites.

Chorioptic Mange: In clinical studies evaluating the efficacy of EPRINEX Pour-On against chorioptic mange mites, mites were not recovered from skin scrapings taken 8 weeks after treatment; however, chronic skin lesions were still present on some animals.

Horn flies: For optimal control of horn flies, as EPRINEX Pour-On provides 7 days of persistent activity against horn flies, the product should be used as part of an integrated control program utilizing other control methods to provide extended control.

DOSAGE

The product is formulated only for external application to beef and dairy cattle. The dose rate is 1 mL/10 kg (22 lb) of body weight. The product should be applied topically along the backline in a narrow strip extending from the withers to the tailhead.

Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.

ADMINISTRATION

Metering Cup with Measure-Squeeze-Pour System

250 mL (8.5 fl oz) Container with 25 mL Metering Cup

1 Liter (33.8 fl oz) Container with 60 mL Metering Cup

This pack contains 1 Metering Cup and 1 dip tube

1.
Insert the dip tube into base of the Metering Cup. Leave the “slotted end” of the dip tube exposed in the bottom of the container.
2.
Unscrew shipping cap from container top.
3.
Screw the Metering Cup onto container top.
4.
Measure: To select the correct dose rate, rotate the adjuster cap (top) in either direction to position the dose indicator to the weight of the animal you want to treat. When body weight is between markings, use the higher setting.
5.
Squeeze the container gently to fill the Metering Cup to the required dose. Release your grip and any excess will return to the container.
6.
Pour: Apply the full dose by tipping and pouring along the backline of the animal until the Metering Cup is empty.
7.
Storage: The Metering Cup should not remain attached to the container when not in use. Detach the Metering Cup after each use and replace the shipping cap to close the container top.

Collapsible Pack (2.5 L/84.5 fl oz, 5 L/169 fl oz, and 10 L/338 fl oz Packs)

Connect the dosing applicator and draw-off tubing to the collapsible pack as follows:

Attach the open end of the draw-off tubing to an appropriate dosing applicator. Attach draw-off tubing to the cap with the stem that is included in the pack (10 L contains two caps – one for inverted use and the other for upright use). Replace the shipping cap with the cap having the draw-off tubing.

Gently prime the dosing applicator, checking for leaks. Follow the dosing applicator manufacturer’s directions for adjusting the dose and proper use and maintenance of the dosing applicator and draw-off tubing.

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