DEXMEDESED- dexmedetomidine hydrochloride injection, solution
Dechra Veterinary Products LLC
CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
DESCRIPTION: Dexmedesed (dexmedetomidine hydrochloride) is a synthetic alpha2 -adrenoreceptor agonist with sedative and analgesic properties. The chemical name is (+)-4-[1-(2,3-dimethylphenyl) ethyl]-1H-imidazole monohydrochloride. It is a white, or almost white, crystalline, water soluble substance having a molecular weight of 236.7.
The molecular formula is C13 H16 N2 ∙ HCl and the structural formula is:
Each mL of Dexmedesed contains 0.5 mg dexmedetomidine hydrochloride, 1.6 mg methylparaben (NF), 0.2 mg propylparaben (NF), 9.0 mg sodium chloride (USP), and water for injection (USP), q.s.
INDICATIONS: Dexmedesed is indicated for use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. Dexmedesed is also indicated for use as a preanesthetic to general anesthesia in dogs and cats.
Dogs: Sedation and Analgesia: 500 mcg/m2 intramuscularly (IM) or 375 mcg/m2 intravenously (IV).
Preanesthesia: 125 or 375 mcg/m2 IM.
The choice of preanesthetic dose depends on the duration and severity of the procedure, as well as the anesthetic regime. The following two tables may be used to determine the correct dexmedetomidine hydrochloride dosage. Note that the mcg/kg dosage decreases as body weight increases. For example, dogs weighing 2 kg are dosed at 28.1 mcg/kg dexmedetomidine hydrochloride IV, compared to dogs weighing 80 kg that are dosed at 8.7 mcg/kg. Due to the small volume of administration, accurate dosing is not possible in dogs weighing less than 2 kg (4.4 lb).
|Dexmedesed 0.5 mg/mL|
|Sedation/analgesia in dogs|
|Dog Weight||Dexmedetomidine hydrochloride375 mcg/m2 IV||Dexmedetomidine hydrochloride500 mcg/m2 IM|
|Dexmedesed 0.5 mg/mL|
|Preanesthesia in dogs|
|Dog Weight||Dexmedetomidine hydrochloride125 mcg/m2 IM||Dexmedetomidine hydrochloride375 mcg/m2 IM|
The use of dexmedetomidine hydrochloride as a preanesthetic markedly reduces anesthetic requirements in dogs. Injectable induction drug requirements for intubation will be reduced between 30% and 60%, depending on the choice of anesthetic and the dexmedetomidine hydrochloride preanesthetic dose. The concentration of inhalation maintenance anesthetic will be reduced between 40% and 60%, depending on the dose of dexmedetomidine hydrochloride. The anesthetic dose should always be titrated against the response of the patient. The choice of anesthetic is left to the discretion of the veterinarian.
Cats: Sedation, Analgesia and Preanesthesia: 40 mcg/kg intramuscularly (IM).
This dose can also be used as a preanesthetic and has been shown to markedly reduce anesthetic requirements in cats. Injectable anesthetic drug requirements for intubation were reduced up to 49%, depending on the choice of induction drug. The concentration of inhalation maintenance anesthetic was reduced between 35% and 44%, depending on the choice of induction drug. The anesthetic dose should always be titrated against the response of the patient.
The following table may be used to determine the correct dexmedetomidine hydrochloride dosage for cats based on body weight.
|Dexmedesed 0.5 mg/mL|
|Sedation/analgesia and preanesthesia in cats|
|Cat Weight||Dexmedetomidine hydrochloride40 mcg/kg IM|
It is recommended that dogs and cats be fasted for 12 hours before treatment with Dexmedesed. An eye lubricant should be applied to cats to prevent corneal desiccation that may result from a reduction in the blink reflex. Following injection of Dexmedesed, the animal should be allowed to rest quietly for 15 minutes; sedation and analgesia occur within 5 to 15 minutes, with peak effects at 30 minutes after dexmedetomidine hydrochloride.
CONTRAINDICATIONS: Do not use Dexmedesed in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue.
As with all alpha2 -adrenoceptor agonists, the potential for isolated cases of hypersensitivity, including paradoxical response (excitation), exists.
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