Dexdomitor: Product Information

DEXDOMITOR- dexmedetomidine hydrochloride injection, solution
Zoetis Inc.

DEXDOMITOR ®
(dexmedetomidine hydrochloride)
Sterile Injectable Solution – 0.1 mg/mL
Sterile Injectable Solution – 0.5 mg/mL
Intramuscular and Intravenous use in Dogs
Intramuscular use in CatsSedative, Analgesic, Preanesthetic

This listing contained the combined text for the 0.1 mg/mL and 0.5 mg/mL solutions.

CAUTION

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

DESCRIPTION

DEXDOMITOR (dexmedetomidine hydrochloride) is a synthetic alpha₂ -adrenoreceptor agonist with sedative and analgesic properties. The chemical name is (+)-4-[1-(2,3-dimethylphenyl) ethyl]-1H-imidazole monohydrochloride. It is a white, or almost white, crystalline, water soluble substance having a molecular weight of 236.7. The molecular formula is C₁₃ H₁₆ N₂ ∙HCl and the structural formula is:

0.1 — Each mL of DEXDOMITOR contains 0.5 mg dexmedetomidine hydrochloride, 1.6 mg methylparaben (NF), 0.2 mg propylparaben (NF), 9.0 mg sodium chloride (USP), and water for injection (USP), q.s.

0.5 — Each mL of DEXDOMITOR contains 0.5 mg dexmedetomidine hydrochloride, 1.6 mg methylparaben (NF), 0.2 mg propylparaben (NF), 9.0 mg sodium chloride (USP), and water for injection (USP), q.s.

INDICATIONS

DEXDOMITOR is indicated for use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. DEXDOMITOR is also indicated for use as a preanesthetic to general anesthesia in dogs and cats.

DOSAGE AND ADMINISTRATION

Dogs — 0.1

Sedation and Analgesia: 500 mcg/m² intramuscularly (IM) or 375 mcg/m² intravenously (IV). Preanesthesia: 125 or 375 mcg/m² IM.

The choice of preanesthetic dose depends on the duration and severity of the procedure, as well as the anesthetic regime. The following two tables may be used to determine the correct dexmedetomidine dosage. Note that the mcg/kg dosage decreases as body weight increases. For example, dogs weighing 2 kg are dosed at 28.1 mcg/kg dexmedetomidine IV, compared to dogs weighing 80 kg that are dosed at 8.7 mcg/kg. Due to the small volume of administration, accurate dosing is not possible in dogs weighing less than 2 kg (4.4 lb).

Table 1: CANINE SEDATION/ANALGESIA DOSE TABLE: Intravenous (IV) and intramuscular (IM) dosing on the basis of body weight.

DEXDOMITOR 0.5 mg/mL
Sedation/analgesia in dogs
DogWeight		Dexmedetomidine375 mcg/m2 IV		Dexmedetomidine500 mcg/m2 IM
lbs	Kg	mcg/kg	mL	mcg/kg	mL
4.4-7	2-3	28.1	0.6	40	0.75
7.1-9	3.1-4	25	0.75	35	1
9.1-11	4.1-5	23	1	30	1.5
11.1-22	5.1-10	19.6	1.45	25	2
22.1-29	10.1-13	16.8	1.9

Table 2: CANINE PREANESTHESIA DOSE TABLE: Intramuscular (IM) dosing on the basis of body weight.

DEXDOMITOR 0.5 mg/mL
Preanesthesia in dogs
DogWeight		Dexmedetomidine125 mcg/m2 IM		Dexmedetomidine375 mcg/m2 IM
lbs	Kg	mcg/kg	mL	mcg/kg	mL
4.4-7	2-3	9.4	0.2	28.1	0.6
7.1-9	3.1-4	8.3	0.25	25	0.75
9.1-11	4.1-5	7.7	0.35	23	1
11.1-22	5.1-10	6.5	0.5	19.6	1.45
22.1-29	10.1-13	5.6	0.65	16.8	1.9
29.1-33	13.1-15	5.2	0.75
33.1-44	15.1-20	4.9	0.85

For higher weight ranges, use DEXDOMITOR’s higher concentration and its associated dosing chart.

The use of dexmedetomidine as a preanesthetic markedly reduces anesthetic requirements in dogs. Injectable induction drug requirements for intubation will be reduced between 30% and 60%, depending on the choice of anesthetic and the dexmedetomidine preanesthetic dose. The concentration of inhalation maintenance anesthetic will be reduced between 40% and 60%, depending on the dose of dexmedetomidine. The anesthetic dose should always be titrated against the response of the patient. The choice of anesthetic is left to the discretion of the veterinarian.