Dectomax: Product Information

DECTOMAX- doramectin injection, solution
Zoetis Inc.

Antiparasitic

1% injectable solution for cattle and swine

10 mg/mL

Approved by FDA under NADA # 141-061

PRODUCT DESCRIPTION

Dectomax injectable solution is a ready-to-use, colorless to pale yellow, sterile solution containing 1% w/v doramectin (10 mg/mL). In cattle, Dectomax is formulated to deliver the recommended dosage (200 mcg/kg of body weight) when given by subcutaneous (SC) or intramuscular (IM) injection at the rate of 1 mL/110 lb of body weight. In swine, Dectomax is formulated to deliver the recommended dosage (300 mcg/kg of body weight) when given by IM injection at the rate of 1 mL/75 lb of body weight.

PRODUCT CHARACTERISTICS

Dectomax injectable solution is a highly active, broad-spectrum parasiticide for parenteral administration to cattle and swine. It contains doramectin, a novel fermentation-derived macrocyclic lactone. Doramectin is isolated from fermentations of selected strains derived from the soil organism Streptomyces avermitilis.

A primary mode of action of macrocyclic lactones is to modulate chloride ion channel activity in the nervous system of nematodes and arthropods. Macrocyclic lactones bind to receptors that increase membrane permeability to chloride ions. This inhibits the electrical activity of nerve cells in nematodes and muscle cells in arthropods and causes paralysis and death of the parasites. In mammals, the neuronal receptors to which macrocyclic lactones bind are localized within the central nervous system (CNS), a site reached by only negligible concentrations of doramectin.

One dose of Dectomax injectable solution effectively treats and controls a wide range of roundworm and arthropod parasites that impair the health and productivity of cattle and swine.

Studies have demonstrated the safety margin of Dectomax injection in cattle and swine. In USA trials, no toxic signs were seen in cattle given up to 25 times the recommended dose, or in swine given up to 10 times the recommended dose. Studies also demonstrated safety in neonatal calves and piglets treated with up to 3 times the recommended dose. In males (bulls and boars) and females (cows and sows during folliculogenesis, implantation, organogenesis, and through gestation), a dose 3 times the recommended dose had no effect on breeding performance.

PRODUCT INDICATIONS

Cattle

Dectomax injectable solution is indicated for the treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, eyeworms, grubs (see PRECAUTIONS), sucking lice (see PRECAUTIONS), and mange mites. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

*
adults
Gastrointestinal Roundworms (adults and fourth stage larvae) Ostertagia ostertagi (including inhibited larvae) O. lyrata Haemonchus placei Trichostrongylus axei T. colubriformis T. longispicularis * Cooperia oncophora C. pectinata * C. punctata C. surnabada (syn. mcmasteri) Bunostomum phlebotomum * Strongyloides papillosus * Oesophagostomum radiatum Trichuris spp.*

Lungworms (adults and fourth stage larvae)Dictyocaulus viviparus Eyeworms (adults)Thelazia spp. Grubs (parasitic stages)Hypoderma bovis H. lineatum Sucking LiceHaematopinus eurysternus Linognathus vituli Solenopotes capillatus Mange MitesPsoroptes bovis Sarcoptes scabiei

1 Adults

Dectomax injectable solution has been proved to effectively control infections and to protect cattle from reinfection with Cooperia oncophora and Haemonchus placei for 14 days, Ostertagia ostertagi for 21 days, and C. punctata , Oesophagostomum radiatum , and Dictyocaulus viviparus for 28 days after treatment.

Swine

Dectomax injectable solution is indicated for the treatment and control of the following species of gastrointestinal roundworms, lungworms, kidney worms, sucking lice (see PRECAUTIONS), and mange mites. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

*
adults
Gastrointestinal Roundworms (adults and fourth stage larvae)Ascaris suum Oesophagostomum dentatum Oesophagostomum quadrispinulatum * Strongyloides ransomi * Hyostrongylus rubidus * Lungworms (adults)Metastrongylus spp. Kidney Worms (adults)Stephanurus dentatus Mange Mites (adults and immature stages)Sarcoptes scabiei var. suis Sucking Lice (adults and immature stages)Haematopinus suis

DOSAGE

Cattle

Administer Dectomax injectable solution at the recommended dosage of 200 mcg doramectin per kg (91 mcg/lb) of body weight. Each mL contains 10 mg of doramectin, sufficient to treat 110 lb (50 kg) of body weight.

Body Weight (lb) Dose (mL)
110 1
220 2
330 3
440 4
550 5
660 6
770 7
880 8
990 9
1,100 10

Swine

Administer Dectomax injectable solution at the recommended dosage of 300 mcg doramectin per kg (136 mcg/lb) of body weight. Each mL contains 10 mg of doramectin, sufficient to treat 75 lb (34 kg) of body weight.

Body Weight (lb) Dose (mL)
15 0.2
30 0.4
45 0.6
60 0.8
75 1.0
150 2.0
225 3.0
300 4.0
375 5.0
450 6.0

Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.

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