Carprovet: Product Information (Page 2 of 3)

REFERENCES:

  1. Baruth H, et al: In Anti-Inflammatory and Anti-Rheumatic Drugs, Vol. II, Newer Anti-Inflammatory Drugs, Rainsford KD, ed. CRC Press, Boca Raton, pp. 33-47, 1986.
  2. Vane JR, Botting RM: Mechanism of action of anti-inflammatory drugs. Scand J Rheumatol 25:102, pp. 9-21.
  3. Grossman CJ, Wiseman J, Lucas FS, et al: Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and COX-2 inhibitors. Inflammation Research 44:253-257, 1995.
  4. Ricketts AP, Lundy KM, Seibel SB: Evaluation of selective inhibition of canine cyclooxygenase 1 and 2 by carprofen and other nonsteroidal anti-inflammatory drugs. Am J Vet Res 59:11, pp. 1441-1446, November 1998.
  5. Ceuppens JL, et al: Non-steroidal anti-inflammatory agents inhibit the synthesis of IgM rheumatoid factor in vitro. Lancet 1:528, 1982.
  6. Ceuppens JL, et al: Endogenous prostaglandin E2 enhances polyclonal immunoglobulin production by ionically inhibiting T suppressor cell activity. Cell Immunol 70:41, 1982.
  7. Schleimer RP, et al: The effects of prostaglandin synthesis inhibition on the immune response. Immunopharmacology 3:205, 1981.
  8. Leung KH, et al: Modulation of the development of cell mediated immunity: possible roles of the products of cyclooxygenase and lipoxygenase pathways of arachidonic acid metabolism. Int J Immunopharmacology 4:195, 1982.
  9. Veit BC: Immunoregulatory activity of cultured-induced suppressor macrophages. Cell Immunol 72:14, 1982.
  10. Schmitt M, et al: Biopharmaceutical evaluation of carprofen following single intravenous, oral, and rectal doses in dogs. Biopharm Drug Dispos 11(7):585-94, 1990.
  11. Kore AM: Toxicology of nonsteroidal anti-inflammatory drugs. Veterinary Clinics of North America, Small Animal Practice 20, March 1990.
  12. Binns SH: Pathogenesis and pathophysiology of ischemic injury in cases of acute renal failure. Compend for Cont Ed 16:1, January 1994.
  13. Boothe DM: Prostaglandins: Physiology and clinical implications. Compend for Cont Ed 6:11, November 1984.
  14. Rubin SI: Nonsteroidal anti-inflammatory drugs, prostaglandins, and the kidney. JAVMA 188:9, May 1986.
  15. Ko CH, Lange DN, Mandsager RE, et al: Effects of butorphanol and carprofen on the minimal alveolar concentration of isoflurane in dogs. JAVMA 217:1025-1028, 2000.

To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet, contact Dechra at 1-866-933-2472. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae

Approved by FDA under ANADA # 200-703

Manufactured for:
Dechra Veterinary Products
7015 College Boulevard, Suite 525
Overland Park, KS 66211 USA

Rev. September 2021

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Dog Owner Information about
Carprovet®
(carprofen tablets)
Caplets
for Osteoarthritis and Post-Surgical Pain
Generic name: carprofen (“car-prō-fen”)

This summary contains important information about Carprovet. You should read this information before you start giving your dog Carprovet and review it each time the prescription is refilled. This sheet is provided only as a summary and does not take the place of instructions from your veterinarian. Talk to your veterinarian if you do not understand any of this information or if you want to know more about Carprovet.

What is Carprovet?

Carprovet is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain and inflammation (soreness) due to osteoarthritis and pain following surgery in dogs. Carprovet is a prescription drug for dogs. It is available as caplets and are given to dogs by mouth.

Osteoarthritis (OA) is a painful condition caused by “wear and tear” of cartilage and other parts of the joints that may result in the following changes or signs in your dog:

  • Limping or lameness
  • Decreased activity or exercise (reluctance to stand, climb stairs, jump or run, or difficulty in performing these activities)
  • Stiffness or decreased movement of joints

To control surgical pain (e.g. for surgeries such as spays, ear procedures or orthopedic repairs) your veterinarian may administer Carprovet before the procedure and recommend that your dog be treated for several days after going home.

What kind of results can I expect when my dog is on Carprovet?

While Carprovet is not a cure for osteoarthritis, it can relieve the pain and inflammation of OA and improve your dog’s mobility.

  • Response varies from dog to dog but can be quite dramatic.
  • In most dogs, improvement can be seen in a matter of days.
  • If Carprovet is discontinued or not given as directed, your dog’s pain and inflammation may come back.

Who should not take Carprovet?

Your dog should not be given Carprovet if he/she:

  • Has had an allergic reaction to carprofen, the active ingredient of Carprovet.
  • Has had an allergic reaction to aspirin or other NSAIDs (for example deracoxib, etodolac, firocoxib, meloxicam, phenylbutazone or tepoxalin) such as hives, facial swelling, or red or itchy skin.

Carprovet should be given to dogs only.

Cats should not be given Carprovet. Call your veterinarian immediately if your cat receives Carprovet. People should not take Carprovet. Keep Carprovet and all medicines out of reach of children. Call your physician immediately if you accidentally take Carprovet.

How to give Carprovet to your dog.

Carprovet should be given according to your veterinarian’s instructions. Your veterinarian will tell you what amount of Carprovet is right for your dog and for how long it should be given. Carprovet should be given by mouth and may be given with or without food.

What to tell/ask your veterinarian before giving Carprovet.

Talk to your veterinarian about:

  • The signs of OA you have observed (for example limping, stiffness).
  • The importance of weight control and exercise in the management of OA.
  • What tests might be done before Carprovet is prescribed.
  • How often your dog may need to be examined by your veterinarian.
  • The risks and benefits of using Carprovet.

Tell your veterinarian if your dog has ever had the following medical problems:

  • Experienced side effects from Carprovet or other NSAIDs, such as aspirin
  • Digestive upset (vomiting and/or diarrhea)
  • Liver disease
  • Kidney disease
  • A bleeding disorder (for example, Von Willebrand’s disease)

Tell your veterinarian about:

  • Any other medical problems or allergies that your dog has now or has had.
  • All medicines that you are giving your dog or plan to give your dog, including those you can get without a prescription.

Tell your veterinarian if your dog is:

  • Pregnant, nursing or if you plan to breed your dog.

What are the possible side effects that may occur in my dog during Carprovet therapy?

Carprovet, like other drugs, may cause some side effects. Serious but rare side effects have been reported in dogs taking NSAIDs, including Carprovet. Serious side effects can occur with or without warning and in rare situations result in death.

The most common NSAID-related side effects generally involve the stomach (such as bleeding ulcers), and liver or kidney problems. Look for the following side effects that can indicate your dog may be having a problem with Carprovet or may have another medical problem:

  • Decrease or increase in appetite
  • Vomiting
  • Change in bowel movements (such as diarrhea, or black, tarry or bloody stools)
  • Change in behavior (such as decreased or increased activity level, incoordination, seizure or aggression)
  • Yellowing of gums, skin, or whites of the eyes (jaundice)
  • Change in drinking habits (frequency, amount consumed)
  • Change in urination habits (frequency, color, or smell)
  • Change in skin (redness, scabs, or scratching)

It is important to stop therapy and contact your veterinarian immediately if you think your dog has a medical problem or side effect from Carprovet therapy. If you have additional questions about possible side effects, talk to your veterinarian.

Can Carprovet be given with other medicines?

Carprovet should not be given with other NSAIDs (for example, aspirin, deracoxib, etodolac, firocoxib, meloxicam, tepoxalin) or steroids (for example, cortisone, dexamethasone, prednisone, triamcinolone).

Tell your veterinarian about all medicines you have given your dog in the past, and any medicines that you are planning to give with Carprovet. This should include other medicines that you can get without a prescription. Your veterinarian may want to check that all of your dog’s medicines can be given together.

What do I do in case my dog eats more than the prescribed amount of Carprovet?

Contact your veterinarian immediately if your dog eats more than the prescribed amount of Carprovet.

What else should I know about Carprovet?

This sheet provides a summary of information about Carprovet. If you have any questions or concerns about Carprovet, or osteoarthritis, or postoperative pain, talk to your veterinarian.

As with all prescribed medicines, Carprovet should only be given to the dog for which it was prescribed. It should be given to your dog only for the condition for which it was prescribed.

It is important to periodically discuss your dog’s response to Carprovet at regular check ups. Your veterinarian will best determine if your dog is responding as expected and if your dog should continue receiving Carprovet.

To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet, contact Dechra at 1-866-933-2472. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae

Approved by FDA under ANADA # 200-703

Manufactured for:
Dechra Veterinary Products
7015 College Boulevard, Suite 525
Overland Park, KS 66211 USA

Rev. September 2021

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