Aquaflor Type A Medicated Article: Product Information

AQUAFLOR TYPE A MEDICATED ARTICLE- florfenicol powder
Schering Corporation

Type A Medicated Article For Use in Freshwater-reared Finfish Feeds Only

Do Not Feed Undiluted

CAUTION

Federal law limits this drug to use under the professional supervision of a licensed veterinarian. Animal feed bearing or containing this veterinary feed directive drug shall be fed to animals only by or upon a lawful veterinary feed directive (VFD) issued by a licensed veterinarian in the course of the veterinarian’s professional practice.

Active Drug Ingredient

Florfenicol 500 g per kg (227.27 g per lb)

Inert ingredients

Lactose and Povidone.

Description

Each kg of Aquaflor® (florfenicol) contains 500 g (1.1 lb) of florfenicol in a palatable base.

Indications

Fish Species Indication Florfenicol(mg/kg bodyweight/day)
Caution: Not for use in recirculating aquaculture systems. The effect of florfenicol on recirculating system biofilters and water quality has not been evaluated. The effects of Aquaflor® (florfenicol) on reproductive performance have not been determined. For catfish, a dose related decrease in hematopoietic/lymphopoietic tissue may occur. The time required for the hematopoietic/lymphopoietic tissues to regenerate was not evaluated.
Freshwater-reared salmonids For the control of mortality due to furunculosis associated with Aeromonas salmonicida. 10
For the control of mortality due to coldwater disease associated with Flavobacterium psychrophilum.
Freshwater-reared finfish For the control of mortality due to columnarisdisease associated with Flavobacterium columnare. Warmwater: 10 -15Others:10
Catfish For the control of mortality due to enteric septicemia associated with Edwardsiella ictaluri. 10 — 15
Freshwater-reared warmwater finfish For the control of mortality due to streptococcal septicemia associated with Streptococcus iniae. 15

RESIDUE WARNING

Feeds containing Aquaflor® (florfenicol) must be withdrawn 15 days prior to slaughter.

IMPORTANT

This product has been evaluated in salmonid and catfish feeds and should be used in feeds nutritionally similar to these evaluated feeds. Refer to the Freedom of Information Summary for details. Must be thoroughly mixed in feeds or surface-coated (top-coated) onto the feeds before use.

Mixing Instructions

For incorporation into feed pellets

For making Aquaflor® (florfenicol) Type C Medicated Feed:

a)
Aquaflor® (florfenicol) is added to other feed ingredients in the mixer prior to extrusion,
b)
the ingredients are mixed thoroughly to insure homogeneity,
c)
the mixture is steam pelleted or extruded and pellets are dried,
d)
medicated feed pellets are mixed/coated with a predetermined amount of fish or vegetable oil, and
e)
at the completion of mixing, the product is transferred to a storage tank for packaging or transport.

For surface-coating (top-coating) onto feed pellets

There are two methods for making Aquaflor® (florfenicol) Type C Medicated Feed by top-coating.

Method 1:

a)
add a known quantity of fish feed into a mixer,
b)
weigh out Aquaflor® (florfenicol),
c)
mix Aquaflor® with feed pellets,
d)
medicated feed pellets are mixed/coated with a predetermined amount of fish or vegetable oil, and
e)
at the completion of mixing, the product is transferred to a storage tank for packaging or transport.

Method 2:

a)
weigh out fish oil or vegetable oil into a bucket,
b)
weigh out Aquaflor® (florfenicol) and mix thoroughly with the oil in the bucket,
c)
add a known quantity of fish feed into a mixer,
d)
add the Aquaflor® (florfenicol) and oil mixture to the feed in the mixer, slowly, while the mixer is running at low speed,
e)
at the completion of mixing, the product is transferred to a storage tank for packaging or transport.

Example of Aquaflor® (florfenicol) Inclusion Rates for Preparation of Type C Medicated Feed
Feeding Rate Florfenicol Concentration in Feed Amount of Aquaflor® (florfenicol) per Ton of Feed Biomass of Fish Medicated per Ton of Feed per 10-day Treatment Period
% Biomass Grams/ton lbs lbs
Dose10 mg/kg Dose15 mg/kg Dose10 mg/kg Dose15 mg/kg
0.5 1,816 2,724 8.00 12.00 40,000
1.0 908 1,362 4.00 6.00 20,000
2.0 454 681 2.00 3.00 10,000
3.0 300 450 1.32 1.98 6,666
5.0 182 273 0.80 1.20 4,000

Feeding Directions

Feed as the sole ration for 10 consecutive days. Aquaflor® (florfenicol) medicated feed should only be administered once disease has been appropriately diagnosed. Feeding fish at a percent of biomass and corresponding florfenicol concentration included in the table above will deliver the appropriate florfenicol dose.

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