Antisedan: Product Information

ANTISEDAN- atipamezole hydrochloride injection, solution
Zoetis Inc.

Sterile Injectable Solution — 5.0 mg/mL

Dexmedetomidine and Medetomidine Reversing Agent

For intramuscular use in dogs only

CAUTION

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

DESCRIPTION

ANTISEDAN (atipamezole hydrochloride) is a synthetic α2 -adrenergic antagonist.

The chemical name is 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride.

The molecular formula is C14 H16 N2 • HCl and structural formula is:

Chemical Structure
(click image for full-size original)

Each mL of ANTISEDAN contains 5.0 mg atipamezole hydrochloride, 1.0 mg methylparaben (NF), 8.5 mg sodium chloride (USP), and water for injection (USP).

INDICATIONS

ANTISEDAN is indicated for the reversal of the sedative and analgesic effects of DEXDOMITOR (dexmedetomidine hydrochloride), and DOMITOR (medetomidine hydrochloride) in dogs.

DOSAGE AND ADMINISTRATION

ANTISEDAN is administered intramuscularly (IM) for reversal of sedation and analgesia regardless of the route used for DEXDOMITOR or DOMITOR. The atipamezole dose for the reversal of IV DEXDOMITOR or DOMITOR is 3750 mcg/m2. The atipamezole dose for the reversal of IM DEXDOMITOR or DOMITOR is 5000 mcg/m2.

The dosage of ANTISEDAN is calculated based on body surface area. Use the following tables to determine the correct injection volume or the correct ANTISEDAN dosage on the basis of kilograms of body weight.

Note that the mcg/kg dosage decreases as body weight increases.

Table 1: Atipamezole dosing for reversal of IV dexmedetomidine- or medetomidine-induced sedation/analgesia:
Dose table for ANTISEDAN (3750 mcg/m2) when dexmedetomidine or medetomidine is given IV
For # lbs For # kg dose = mcg/kg volume = mL ANTISEDAN
4-7 2-3 300 0.1
7-9 3-4 250 0.15
9-11 4-5 230 0.2
11-22 5-10 200 0.3
22-33 10-15 170 0.4
33-44 15-20 150 0.5
44-55 20-25 140 0.6
55-66 25-30 130 0.7
66-81 30-37 120 0.8
81-99 37-45 110 0.9
99-110 45-50 105 1.0
110-132 50-60 100 1.1
132-143 60-65 95 1.2
143-165 65-75 93 1.3
165-176 75-80 91 1.4
>176 >80 90 1.5
Table 2: Atipamezole dosing for reversal of IM dexmedetomidine- or medetomidine-induced sedation/analgesia:
Dose table for ANTISEDAN (5000 mcg/m2) when dexmedetomidine or medetomidine is given IM
For # lbs For # kg dose = mcg/kg volume = mL ANTISEDAN
4-7 2-3 400 0.15
7-9 3-4 350 0.2
9-11 4-5 300 0.3
11-22 5-10 250 0.4
22-29 10-13 230 0.5
29-33 13-15 210 0.6
33-44 15-20 200 0.7
44-55 20-25 180 0.8
55-66 25-30 170 0.9
66-73 30-33 160 1.0
73-81 33-37 150 1.1
81-99 37-45 145 1.2
99-110 45-50 140 1.3
110-121 50-55 135 1.4
121-132 55-60 130 1.5
132-143 60-65 128 1.6
143-154 65-70 125 1.7
154-176 70-80 123 1.8
>176 >80 120 1.9
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